The purpose of this study was to examed the pain relief effects of myofascial pain syndrome patient by post-isometric relaxation. From July, 1996 to January, 1997, PIR was applied to myofascial pain syndrome associated with musculoskelatal lesions and was examed on 17 muscles in 98 patients at Sun General Hospital, Taejon city. The results of this study were as follows ; 1. Immediate pain relief group was 58(59%). 2. Only tenderness relief group was 24(25%). 3. No effect group was 16(16%). These results could be confirmed that the increased tension of the affected muscles with the resulting pain relieved by restoring the full stretch length of the muscle by PIR.