The present experiment was desined to examine catecholamines, 5-hydroxytryptamine, amino acids, malondialdehyde(MDA) and free radical scavening activity, by administering Cheonmagudeungyeum extract of a variety of concentraction to senile brain The results were summarized as followings: 1. Cheonmagudeungyeum significantly increased noradrenaline in the hippocampus and hypothalamus of the brain tissue of senile rats, and even though Cheonmagudeungyeum increased noradrenaline also in other brain tissue, there was no significance. 2. Cheonmagudeungyeum had no effects on dopamine changes in all brain tissue of senile rats. 3. Cheonmagudeungyeum significantly increased 5-hydrotryptamine in cerebellum, but decreased in other brain tissue. 4. Cheonmagudeungyeum increased amino acid in the brain tissue of senile rats. 5. Cheonmagudeungyeum significantly decresed MDA and free radical in the brain tissue of senile rats. According to the above results, Cheonmagudeungyeum is assumed to improve brain function by reacting on biochemical of the senile brain, and that Cheonmagudeungyeum can be used to treat regressive brain disease carrying symptoms of psychoactive disorders.