- 세프라딘의 용출에 미치는 결정형의 영향
- ㆍ 저자명
- 손영택,김지선,Sohn. Young-Taek,Kim. Ji-Seon
- ㆍ 간행물명
- 藥劑學會誌
- ㆍ 권/호정보
- 1998년|28권 2호|pp.115-119 (5 pages)
- ㆍ 발행정보
- 한국약제학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
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Five polymorphic modifications of Cephradin were prepared by recrystallization from organic solvents. The isolated crystal forms were characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and X-ray crystallography powder diffractometry. Modificaition 1 was the most stable form and decomposed at $201.3^{circ}C$. Modification 3 and 4 were metastable. The dissolution of modification 3 and 4 was faster than that of marketed form.