The age of specialization is upon physical therapy, as evidenced by the many special interest group. One of the special interest is manual therapy, which is the study of neurology, biomechanic, behavior science and pathology as well as the application of evaluative and treatment techniques of the neuromusculoskeletal system. Trend of manual therapy cover the whole medical in Europe. but America has two categories which is the neurologic manual therapy and the orthopedic manual therapy. The neurologic manual therapy was integrated with theory of PNF, Bobath technique, Vojta which is neurophysiologic approach concept. It is called motor control. A key aspect of the motor control requires a through knowledge of neurobiologic, biomechanic, and behavioral science. The orthopedic manual therapy runs to the evaluation and treatment of joints and their surrounding structures increase or decrease mobility and Fain control. In this article has to define and clarify the basic concepts of orthopedic manual therapy by comparing the general concepts, evaluation schemes, and treatment procedures of John McM Mennell, James Cyriax, Geoffrey Maitland, Freddy Kaltenborn and Ola Grimsby.