In this paper, we find the values of near-end crosstalk coefficients in dual-offset stripline of a FR-4 multilayer PCB by an analytic method and a HSPICE simulation method, define calculation errors inananlytic method and the application range, simulate near-end crosstalk coefficients of the FCT(Fast CMOS TTL) in complicated dual-offset stripline by HSPICE and analyze near-end crosstalk and far-end crosstalk coefficients in dual-offset stripline. So, we analyze coupling structure of the near-end crosstalk and far-end crosstalk in the complicated dual-offset striplines that are 1[pF] capacitors termainated, and define a coupling formula of near-end crosstalk and far-end crosstalk coefficients dual-offset striplines.