This paper focuses on the optimal replacement time of engine modules of the F16 aircraft. Generally, the optimal replacement time of those should be determined to minimize the replacement cost due to out of order and opportunistic replacement cost of operation cost of remaining period. This paper determined the optimal replacement time by using the opportunistic replacement algorithm that is developed by Forbes and Wyatt. Some real data are utilized but a few data is estimated due to limitation of data. As a result, fan module only reaches to the opportunistic replacement time. The optimal replacement time of the fan module is derived as 1740 cycles. Therefore, the optimal replacement policy of engine modules of the F16 is that fan module should be replaced whenever it is out of order under 1740 cycles and whenever core module is out of order over 1740 cycles.