In the direct numerical optimization method, the aerodynamic coefficients of the airfoil designed by one-point design can be deteriorated at other operating points. Therefore, the capacity of the multi-point design is indispensable for actual airfoil design. In this paper, the two-point design of transonic airfoils is studied based on the Navier-Stokes equations flow solver and the feasible direction optimization algorithm, and the effects of weighting parameter were analyzed and compared. The results show that the airfoils designed by two-point design satisfy the performances at the peripheral regions of two operating points concurrently and have the favorable aerodynamic characteristics at the point which has larger weighting parameter than the other point.