It is common to assume identical allowable safety factors in static strength defined by mean stress and in fatigue, defined by stress amplitude. Under the load with asymmetrical cycles the safety factor is not the same. In this paper, with the consideration of unequal allowable safety (actors a general method for estimating fatigue reliability of a machine element under a combined state of stress is derived based on the theory proposed by Prof. Kececioglu and a normal distribution. The calculation of fatigue reliability fur limited life is discussed with example.