Some design formulas and design procedures for single and multiple tuned liquid column dampers (TLCDs) are proposed in this study. Previous studies show that if the properties of the TLCD system are properly selected then the TLCD could be as effective as the traditional tuned mass dampers. In addition, the TLCD system offers advantages such as flexibility in terms of installation, little maintenance required, and potentials for multiple usage, etc., which are incomparable by other mechanical types of dampers. In this paper, a set of optimal properties such as length and head loss of a TLCD system are derived under the assumption that the building vibrates in a dominate mode and is subjected to Gaussian white noise excitation. A design procedure for a single TLCD system will be illustrated and discussed. Due to the nonlinearity in the damping term, the TLCD system is sensitive to the loading intensity. This loading sensitivity could limit the application range of the TLCD system. It will be shown in this paper that such a nonlinear effect can be reduced by using multiple TLCDs. As a demonstrative example, the control effects on a flexible building modeled as a single degree-of-freedom system subjected to white noise excitation will be analyzed and discussed using single or multiple TLCDs.