This study is focussed on an optimal vehicle routing model for multi-supply centers in two-echelon logistic system. The aim of this study is to deliver goods for demand sites with optimal decision. This study investigated an integrated model using step-by-step approach based on relationship that exists between the inventory allocation and vehicle routing with restricted amount of inventory and transportations such as the capability of supply centers, vehicle capacity and transportation parameters. Three sub-models are developed: 1) sector-clustering model, 2) a vehicle-routing model based on clustering and a heuristic algorithm, and 3) a vehicle route scheduling model using TSP-solver based on genetic and branch-and-bound algorithm. Also, we have developed computer programs for each sub-models and user interface with visualization for major inputs and outputs. The application and superior performance of the proposed model are demonstrated by several sample runs for the inventory-allocation and vehicle routing problems.