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서지반출
조구등(釣鉤藤)이 일측(一側) 전정기관(前庭器官) 손상(損像) 흰쥐의 전정보상(前庭補償)에 미치는 영향(影響)
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  • 조구등(釣鉤藤)이 일측(一側) 전정기관(前庭器官) 손상(損像) 흰쥐의 전정보상(前庭補償)에 미치는 영향(影響)
저자명
송진호,이성호,김민선,손인철,박병림,김재효,Song. Jin-Ho,Lee. Sung-Ho,Kim. Min-Sun,Sohn. In-Chul,Park. Byung-Rim,Kim. Jae-Hyo
간행물명
大韓韓醫學會誌
권/호정보
1999년|20권 3호|pp.66-76 (11 pages)
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대한한의학회
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정기간행물|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The purpose of this study was to asses the etlect of Uncaria rhynchophylla (UR). one of the oriental herbs having a capability to block calcium channels, on affecting vestibular compensation (VC) in Sprague - Dawley rats. Animals were divided into a drug treatment group receiving, UR per oral for 10 days preceding unilateral labyrinthectomy (ULX) and a control group with saline ingestion, To evaluate behavioral changes. horizontal spontaneous nystagmus (SN) and roll head tilt (RHT) were recorded by a video camem with zoom lens in the course of vestibular compensation (VC). Immunohistochemical staining was performed by conventional ABC method to visualize cFos-like immunoreactive (cFLI) neurons in the medial vestibular nuclei (MVN) and cFLI cells were counted by image analyzer. Bodyweight was increased significantly, about 35g, by UR treatment for 10 clays before ULX. Compared with the control group, the drug group showed significant reduction of RHT 6 hrs after ULX as well as fast disappearance of SN at early stages of vestibular compensation. Also, recovery of the spatial and temporal cFLI expressions in the bilateral MVN was accelerated 24 hrs after ULX. These results suggest that Uncaria rhynchophyila has a beneficial effect to ameliorate vestibular compensation in unilateral labryinthectomized rats.