$O_3$, one of the air pollutants, has been related increasing morbidity rates due to respiratory damages. To investigate the effect of Ikgieum(益氣飮) on rats induced by exposur of $O_3$, an experimental study was done the changes on white blood cell(WBC), Erythrocyte sedimentation rate(ESR), $pCO_2$ and, $pO_2$ in Blood. The experimental groups are the Normal group, Control group and Sample group(administered Ikgieum to rats induced by exposur $O_3$). The results were as follows; 1. The change on WBC on rats induced by exposur of $O_3$ were made significant differences in Sample group compared with Cntrol group. 2. ESR were made is significant differences in Sample group compared with Control group. 3. $pCO_2$ and $pO_2$ were made significant differences in Sample group compared with control group.