A model is constructed to evaluate the mode III stress intensity factor(SIF) for orthotropic three-layered material with a center crack subjected to uniform anti-plane shear loading. A mixed boundary value problem is formulated by Fourier integral transform method and a Fredholm integral equation of the second kind is derived. The integral equation is numerically analyzed to evaluate the effects of the ratio of shear modulus, strength of each layer and crack length to layer thickness on the stress intensity factor.