Activity-guided fractionation of the whole plant of Solidago virga-aurea var. gigantea MIQ. (Compositae) has led to the isolation of three cytotoxic compounds, erythrodial-3-acetate (1), $alpha$-tocopherol-quinone (2), and trans-phytol (3) from the hexane soluble fraction. It is the first report of those compounds from the genus.