Hydrotalcite was prepared by reacting with sodium carbonate, magnesium oxide and aluminum sulfate solutions in this study. The optimum synthesis conditions based on the yield of the product were established by applying Box-Wilson experimental design. It was found that the optimum synthesis conditions of hydrotalcite were as follows; reacting temperature : 48~63$^{circ}C$, concentration of reactant solution : about 20%, molar concentration ratio of two reactants [MgO]/[Al. sulfate] ; 7.35~8.1, temperature of washing water : 34.4~37.4$^{circ}C$, drying temperature : 74~81.5$^{circ}C$. The physicochemical properties of hydrotalcite as medicine were studied by use of chemical analysis, D.S.C. thermogram, bulk volume test and acid consuming capacity measurements.