The use of structural wood based panels like plywood, OSB in many applications involves the use of nails, and data on the performance of panel-nail connection are needed for design and comparative purpose. This study was carried out to develop basic information on nail performance(withdrawal, embedding, nailhead push through) with water absorption in plywood and OSB. In withdrawal resistance test, initial stiffness of plywood performed better than OSB in 24hr soaked condition. The soaked condition reduced average nail withdrawal resistance value about 46% (12d mail), 53%(8d nail) in OSB, 17%(12d mail), 24%(8d mail) in plywood. The nail embedding strength of plywood also performed better than that of OSB and retention value(wet strength/dry strength) yielded similar in each nail types. The nail head push through capacity of OSB was higher than that of plywood in dry condition, but equal or lower in soaked condition. Therefore, critical consideration about structural panels is required in moist applications. The average values of nail withdrawal, nail embedding strength and nail head push through resistance of tested materials meet the minimum requirement of various specification and standards.