This study aims to analyze the role of TST for regional development in terms of university-research institutes-industry interaction. In particular, it focuses on the spin-off activities from research institutes and universities and their support mechanisms. This study consists of following three sections. This study consists of following three sections. Firstly, we describe the role and characteristics of research institutes and universities as the foundation of high technology business spin-off activities in the region. Secondly, the mechanisms for active technology transfer and business incubation are identified in terms of university-research institute and industry interaction in TST. Thirdly, important lessons for the development of technopolis are suggested from the view point of experiences of TST.