In this paper, the fluid-structure interaction of large floating structures has been rigorously analyzed and the shear effect on the structural deformation has been investigated in oblique waves. A constant panel method(CPM) based on the Green function method is implemented for computing the hydrodynamic pressure, while a finite element method(FEM) is applied for the structural response based on the Mindlin plate theory with including shear deformation. In order to validate the method, we compared numerical results with experimental ones of Mega Float carried out by Yago & Endo in head waves. General behavior shows good agreement but the local displacement at the ends is slightly different. The numerical results show that the radiation pressure due to the fluid-structure interaction is locally larger than that of wave excitation and mooring devices greatly reduce the response. It is observed that the shear effects among the total deformation constitutes about 4% in the case of Mega Float in oblique waves.