We are concerned with the optimal design of flexible manufacturing cells in this study, thus try to suggest the detail information for each resource on the optimal conditions. Object oriented simulation technology is used to write models more easily and to execute simulation running time more rapidly, and the optimal level of relevant decision variables is probed by response surface methodology(RSM), which is well known for the optimization technology based on experiment design and regression equation. We investigate the optimal level for the number of pallets and the speed of AGVs of FMC systems, carry out the performance analysis of this system. Consequently we suggest systematic procedures for the optimization of FMCs in detail design stage.