This paper proposes an adaptive sliding mode control scheme for an autopilot design of Skid-to-Turn (STT) missiles. The feedback linearization controller eliminates nonlinear terms in STT dynamics and makes the entire system linear. But the modeling errors in dynamics and the external disturbances exert bad influence on the performance of the feedback linearization controller. To handle these uncertainties, an adaptive control scheme is developed, where a bound of the uncertainties is estimated by an adaptive law based on a sliding surface. The asymptotic output tracking is proved by using the Lyapunov stability theory. Simulations for STT missiles illustrate the validity of the proposed scheme.