Butterhead lettuce was grown hydroponically in a plant factory during summer season. To decrease the occurrence of tipburn and increase productivity, optimum cultivars, substrates, gully slope and height, and the amount of irrigation were evaluated in this experiment. Cultivars ‘Rex’ and ‘Flandria’ showed higher productivity with less tipburn as compared to the others in spite of lower growth rates and appeared to be suitable cultivars during summer season. Cocopeat showed high productivity due to superior physio-chemical characteristics. Appropriate gully slope which makes nutrient solution easy to flow was shown to be 1 to 2%. The amount of irrigation was appropriate at 2$ell$/gully. Higher growth of the butterhead lettuce observed when the bed was at a lower position. Low bed was thought to be good for lettuce growth with proper humidity and average temperatures.