This paper presents a control gain tuning scheme for multi-axis PID control systems by Taguchi method. As an experimental set-up, a parallel mechanism machine tool has been selected. This machine has eight servodrives and each servodrive has four control gains, respectively. Therefore, total 32 control gains have to be tuned. Through a series of design of experiments, an optimal and robust set of PID control gains is tuned. The index of the sum of position error and velocity error is reduced to 61.4% after the experimental gain tuning regardless of the feedrate variation.