In this paper, an efficient method of analysis and design of fault detection filter is presented. Since the directional constraint is applied to the eigenstructure associated with the detection space, an eigenvector is determined by the eigenvalues associated with other eigenvectors. Further, the assignment of a pair of eigenvalue and eigenvector leads to the fixation of overall eigenstructure related with the detection space. Using the transmission zeros and the transmission zero vectors, these phenomenon are clearly proven, and an efficient algorithm for design of the fault detection filters is presented.