A deep sea vehicle must be designed to ensure its safety under ultra-high pressure circumstances. If a pressure housing of a deepsea vehicle is collapsed by ultra-high pressure, the deepsea vehicle may be lost. The objective of this paper is to introduce a design collapse pressure for the deep sea pressure vessel which is composed of one cylinder and two hemispheres. Especially the collapse pressure of hemispherical shell with a hole at top is analyzed by a variational approach (weighted residual method). And for the purpose of design, the salty factor of collapse pressure is presented which is analyzed by interpolation method.