This study is conducted to test an effect of the guided Imagery program on artificially induced pain and to develop an effective nursing intervention for patients with pain. The subjects of this study were 37 normal female university students. The data were collected from September 1998 to December 1998. And two group non-equal quasi -experimental research with pre and post design was used in this study, The data were analyzed with the SPSS $PC^+$ program with percentage, t-test, paired t-test and ANCOVA. The results of this study were as follows : 1. There are no significant differences of systolic blood pressure between groups. 2. The experimental group showed significantly lower diastolic blood pressure than control group after treatment. 3. There are no significant differences of pulse rate between groups. 4. The experimental group showed significantly higher body temperature than control group after treatment. 5. There are no significant differences of pain intensity between groups. 6. There are no significant differences of pain sensation between groups. 7. There are no significant differences of perceived pain tolerance time between groups. 8. The experimental group showed significantly longer real pain tolerance time than control group after treatment. 9. There are no significant differences of anxiety scores between groups. 10. There are no significant differences of Self-esteem scores between groups. 11. There are no significant differences of Self-esteem scores between groups. 12. There are no significant differences of imagability scores between groups. 13. The post-experimental group showed significantly higher relaxation rate than pre -experimental group. 14. There are no significant differences of imaging depth degree between pre-experimental group and post-experimental group. From the above results, it can be concluded that 1. This guided imagery program could be recommenced as an effective nursing intervention to relieve pain. 2. A follow up study is needed to identify long-term effects.