Evolutionary Operation(EVOP) is a method for continuously monitoring and improving a full-scale process to get an optimal operating condition while production is under way. To avoid appreciable changes in the product quality characteristics only small changes are made in the levels of the process variables. One of the reasons why EVOP is not so popular is that people in charge of the EVOP is blamed when the EVOP does not produce good results. We present an EVOP procedure when prior information of the relationship between defect types and process variables is known. The procedure is illustrated with an injection molding case study.