I investigated that tyrosine hydroxylase immunoreactive cells distribution in mesencephalon of korean native goat newborn by immunohistochemical method. The results obtained in this study were summarized as following. 1. It were observed TH-IR cells in substantia nigra pars compacta, ventral tegmental area, substantia nigra pars reticular, central linear nucleus and retrorubral field of Midbrian. 2. TH-IR cells were observed that to mass on several areas in substantia nigra pars compacta and substantia nigra pars reticular. 3. TH-IR cell process observed short or non and it were protruded irregular direction.