Optimization of chassis frame is performed according to the minimization of eleven responses representing one total frame weight, three natural frequencies and seven strength limits of chassis frame that are analyzed by using each response surface model from D-optimal design of experiments. After each response surface model is constructed form D-optimal design and random orthogonal array, the main effect and sensitivity analyses are successfully carried out by using this approximated regression model and the optimal solutions are obtained by using a nonlinear programming method. The response surface models and the optimization algorithms are used together to obtain the optimal design of chassis frame. The eleven-polynomial response surface models of the thirteen frame members (design factors) are constructed by using D-optimal Design and the multi-disciplinary design optimization is also performed by applying dual response analysis