This paper presents the multi-channel active vibration control of a flexible plate of the acoustically loaded enclosure. The flexible plate was excited acoustically with sinusoidal and white noise input. The control was performed by two piezo ceramic actuators and two accelerometers. The experimental results were compared with the single channel control results. In the case of white noise input, 20 dB of vibration reduction was achieved below 300Hz frequency range. The experimental results demonstrate that multi-channel filtered-x LMS algorithm is effective than single-channel filtered-x LMS algorithm in active vibration control of plate.