The purpose of this study is to identify the effect of the voluntary program experience with curriculum on self-esteem and depression in nursing college students. The research design utilized in this study was one group pre test-post test design. The data were gathered two times with questionnaire. First data were gathered before voluntary activity. And second data were gathered after instruction and five times voluntary activity. The data were analized by frequency, paired t-test. t-test. and ANOVA using the SAS program. The results were as follows 1. After the activity the scores of self-esteem were significantly higher than before the activity. 2. After the activity the scores of depression were significantly lower than before the activity. 3. The relationship between self-esteem and depression were negatives in both before and after the activity. 4. Before voluntary activity the scores of self-esteem in the class choosing the Culture Exploration were significantly high. but after the activity the scores of self-esteem were not significantly different. 5. As opinion on attendance of lecture class of voluntary activity program. before voluntary activity the scores of depression were not significantly different. but after the activity the scores of depression were significantly different.