This study was to develop an effective itraconazole liquid preparation which exhibits an enhanced bioavailability. The solubility of itraconazole was increased (72-fold) in itraconazole liquid preparation as compared with itraconazole powder. The dissolution rate of itraconazole was higher for itraconazole liquid preparation filled into a hard gelatin capsule with 90% release within 20 min as compared to 55% for $Sporanox^{circledR}$capsules. The oral absorption of itraconazole liquid preparation and $Sporanox^{circledR}$tablets were studied in the rat. The area under the concentration-time curve $(AUC_{0-24hr})$ of itraconazole liquid preparation ($90.25;{pm};8.36;{mu}g{cdot}hr/ml$) increased by 6.2 times compared to that of Sporanox tablets ($14.58;{pm};1.26;{mu}g{cdot}hr/ml$) after oral administration of itraconazole 15 mg/rat each. $C_{max}$ also increased to $6.87;{pm};1.15;{mu}g/ml$ after administration of liquid preparation $1.58;{pm};0.16;{mu}g/ml$ of $Sporanox^{circledR}$tablets. These results indicate that in vivo bioavailability of itraconazole liquid preparation was significantly enhanced as compared with $Sporanox^{circledR}$tablets.