Upgrade development of a high pressure ratio centrifugal compressor in marine engine turbochargers is presented. A new matched operating point at increased speed of rotation was determined through system cycle analysis using the exisitng test data of turbine performance. Under some severe restrictions for geometric parameters, the state-of-the-art methods of both aerodynamic design and CFD analysis were applied, in which only an impeller, a vaned diffusor and some part of casing wall were modified. Prototype hardware was fabricated and assembled for system performance tests. Excellent performance in pressure ratio and efficiency was obtained over whole speed region. Reduced surge and choke margin was, however, observed at design speed of rotation.