For any S-flat module RM(which will be called endoflat) with a commutaitve ring R with identity, where S is the endomorphism ring RM, the fact that every epimorphism is an automorphism has been proved and the Jacobson Radical Rad(S) of S is described as follow; Rad(S) = { f$in$S｜Imf=Mf is small in M} = {f$in$S｜Imf $leq$Rad(M)}. Additionally for any quasi-injective endo-flat module RM, the fact that every monomorphism is an automorphism has been proved and the Jacobson Radical Rad(S) for any quasi-injective endo-flat module has been studied too. Also some equivalent conditions for the semi-primitivity of any faithful endo-flat module RM with the open Jacobson Radical Rad(M) and those for the semi-simplicity of any faithful endo-flat quasi-injective module RM with the closed Socle Soc(M) have been studied.