Cytotoxic Activities of 6-Arylamino-7-halo-5,8-quinolinediones against Human Tumor Cell Lines

Cytotoxic Activities of 6-Arylamino-7-halo-5,8-quinolinediones against Human Tumor Cell Lines
Cytotoxic Activities of 6-Arylamino-7-halo-5,8-quinolinediones against Human Tumor Cell Lines

ㆍ 저자명: Ryu. Chung-Kyu,Kang. Hye-Yung,Yi. Yu-Jini,Lee. Chong-Ock
ㆍ 간행물명: Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
ㆍ 권/호정보: 2000년|23권 1호|pp.42-45 (4 pages)
ㆍ 발행정보: 대한약학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

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기타언어초록

6-Arylamino-7-halo-5,8-quinolinediones (4a-4k, 5a-5b) were tested for in vitro cytotoxicity against human solid tumor cell lines such as A 549 (non-small cell lung). SK-OV-3 (ovarian), SK-MEL-2 (melanoma), HCT-15 (colon) and XF 498 (CNS) by SRB assay. The arylamino-7-chloro-5,8-quinolinediones 4 were also evaluated for cyclin-dependent kinase (CDK2 and CDK4) inhibitory effect. Among them, the 5,8-quinolinediones 4a and 5a with 7-(4-fluorophenyl) amino group were found to be potent cytotoxic against HCT 15, SKOV-3 and XF 498, and the compounds 4f and 4i showed inhibitory activities for the CDK4.

키워드

6-Arylamino-7-halo-5 8-quinoinediones Cytotoxicity Human tumor cell lines CDK4

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