In this study, we fabricated the advanced telemetry system that transmitting media use radio frequency(RF) for the middle range measurement of the physiological signals and receiving media use optical for electromagnetic interference problem. The telemetry system within a size of 65$ imes$125$ imes$45mm consists of three parts: a RF transmitter, a optical receiver and a physiological signal processing CMOS one chip. Advantages of proposed telemetry system is wireless middle range(50m) FM transmission, reduce electromagnetic interference to a minimum which enables a comfortable bed-side telemetry system.