In order to improve the function of a door seal, its section design technique is discussed in this study, Its roles are prevention of an inflow of dusts, noise interception, insulation, wateproof, and the vibroisolating action which reduces vibration between the body and the door of a car while running, and the buffer action which sustain the proper reacting force as the door is closed. In this study, the optimal cross section of a door seal is designed using nonlinear finite element analysis (commercial finete element analysis program EASi-SEAL) and tables of orthogonal arralys with respect to relations between door and door seal to secure the satisfactory airtight property with the minimum force to shut the door.