The design of experiment(DOE) is getting more attention in the engineering community since it is easy to understand and apply. Recently, engineering designers are adopting DOE with orthogonal arrays when they want to design products in a discrete design space. In this research, a design flow with orthogonal arrays is defined for structural design according to the general DOE. The design problem is defined as a general structural optimization problem. Sensitivity information is evaluated by the analysis of variance(ANOVA), and an optimum design is determined from analysis of means(ANOM). Interactions between design variables are investigated to achieve additivity which should be valid in DOE. When strong interactions exit, a method is proposed. Some methods to consider the problem are suggested.