In may experimental situations, whenever a block design is used, the block effect is usually considered to be fixed. There are, however, experimental situations in which it should be treated as random. The choice of a blocking arrangement for a response surface design can have a considerable effect on estimating the mean response and on the size of he prediction variance even if the experimental runs re the same. Therefore, care should be exercised in the selection of blocks. In this paper, in the presence of a random block effect, we propose a graphical method or evaluating the effect of blocking in response surface designs using cuboidal regions. This graphical method can be used to investigate how the blocking has influence on the prediction variance throughout all experimental regions of interest when this region is cuboidal, and compare the block effects in the cases of the orthogonal and non-orthogonal block designs, respectively.