The purpose of this work is to explain the necessity and operation method of college mathematics clinic, investigating the reason why college students like and dislike mathematics. It is difficult for each professor alone to operate college mathematics clinic without students` helping. They need to work together. For mathematics clinic operation, the following will be practiced: 1) make use of math-class, 2) help of math-club, 3) make internet homepage, 4) use of university institution and laboratory.