Evaporation heat transfer characteristics were studied in a horizontal tube using R22/R114 non-azotropic refrigerant mixture. the heat transfer coefficient was high in the upper part for pure refrigerants, and heat transfer coefficient was low in the lower part for refrigerant mixtures. In the low quality region where nucleate boiling was dominant, the average heat transfer coefficient was low. In the region where forced convection was dominant, heat transfer coefficient was high. Results show that the heat transfer coefficient for pure refrigerants obtained by experiments were lower than those of Yoshida et al. but agreed well with Jung et al., and Chen et al. data. But the heat transfer coefficients for refrigerant mixtures were lower about 20% than those predicted by the equation for pure refrigerant.