Tube hydroforming is recently drawing attention of automotive industries due to its several advantages over conventional methods. It can produce wide range of products such as subframes, engine cradles, and exhaust manifolds with cheaper production cost by reducing overall number of processes. h successful tube hydroforming depends on the reasonable combination of the internal pressure and axial load at the tube ends. This paper deals with the optimal process design of hydroforming process using the genetic algorithm and neural network. An optimization technique is used in order to minimize the tube thickness variation by determining the optimal loading path in the tube expansion forming and the tube T-shape forming process.