Seismic behavior of 3-dimensional setback structures showing abrupt reductions of the floor size within the structure height and the effect of in-plane deformations of floor slabs on the seismic behavior of those structures are investigated. To find out general seismic behavior of 3-dimensional setback structures two parameters, level of setback(L_s) and degree of setback(R_s) are used. Analysis results obtained from forty eight setback structures show that a sudden change in story shear near setback level is occurred for irregular setback structures. The effect of in-plane deformation of floor slabs on the seismic behavior of setback structures is greatly influenced by the arrangement of lateral load resisting elements and it is more pronounced for frame-shear wall system showing large difference in stiffness among the lateral load resisting elements. The in-plane deformation of floor slabs results in reduced base shear, especially for FW-type structures with L_s=1.0. Also, it brings about reduced story shear for the lateral load resisting element with shear wall and increase in story shear lot the lateral load resisting element without shear wall. The in-plane deformation of floor slabs at the base portion and/or tower portion due to difference in stiffness among the lateral load resisting elements brings about increment of floor displacements at all floor level.