Xiexiafa is the one of eight methodes of treatment, the purgatives of oriental medicine was originated from Shanghanlun written by Zhangzhongjing. Traditionally Xiexiafa has been used to treat constipation. But All kinds of researches on Xiexiafa made purgatives possible to use variously for the disease of internal medicine. In the research on clinical use of Xiexiafa, the results were as follow. Xiexiafa is available on emergency medicine because of instant relief. It has an ability of preventive medicine and economical effect. It was considered to treat hard to cure and chronic diseases made by Sushi, Rexie, Shuijie, Tanzhi, Xuxie etc. Considering strong side effects of Xiexiafa and patient conditions, it must be used carefully.