- 띠미로버섯 중 25-Epi, $3{alpha}-Carboxyacetylquercinic$ Acid의 분리정제, 구조결정 및 생리활성
- ㆍ 저자명
- 배강규,민태진,Bae. Kang-Gyu,Min. Tae-Jin
- ㆍ 간행물명
- 대한화학회지
- ㆍ 권/호정보
- 2000년|44권 1호|pp.37-44 (8 pages)
- ㆍ 발행정보
- 대한화학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
띠미로버섯의 에탄올 추출물 중 25-Epi, $3{alpha}-carboxyacetylquercinic$ acid의 두 구조, 항균활성 및 항암활성을 연구하였다. 화합물 1의 녹는점과 분자량은 각각 $167{sim}168^{circ}C$, 572였고, 몰 흡광 계수는 208 nm에서 5,040이었다. 여러 분광학적 성질로부터 이는 24S, 25S, $3{alpha}-carboxyacetylquercinic$ acid로 확인되었고, 곰팡이, 효모 및 세균들에 대한 항균활성과 항암활성($IC_{50}=64.5;{mu}M$)이 있었다. 화합물 2의 녹는점, 분자량 및 몰흡광 계수는 각각 $233{sim}235^
In order to develope bioactive substances, dried fmit body of Daedalea dickinsii collected from Taeback mountain was extracted with ethanol, The compounds 1 and 2 were purified by solvent extraction, silica gel column chromatography and recrystallization from the ethanol extracts. Melting point, molecular weight and molar extinction coefficient of the compound 1 were estimated to be $167{sim}168^{circ}C$, 572 and 5,040 at 208 nm. The structure of this compound 1 has been elucidated to be 24S, 25S, $3{alpha}-carboxyacetylquercinic$ acid using spectroscopic properties. This compound showed antibiotic activities against fungi, yeasts and bacteria and it also showed anticancer activity $IC_{50}=64.5;{mu}M$) against Korean stomach cancer cell. Melting point, molecular weight and molar extinction coefficient of the compound 2 were estimated to be $233{sim}235^