저자들은 B형 간염 바이러스에 수직 감염된 13세 된 XLA 환아에서 발생한 간세포 암종 1례를 경험하였기에 보고하는 바이며, 간세포 암종의 발생은 XLA 환아에서 수직 감염된 B형 간염 바이러스가 효과적으로 제거되지 못해 발생되었을 것으로 사료된다.
X-linked agammaglobulinemia (XLA) is a primary inherited B-cell immunodeficiency. The prevalence of neoplastic disease in patients with XLA is approximatedly 0.7%. The most frequent tumor is lymphoreticular malignancy. We report a case of hepatocellular carcinoma (HCC) in a 13-year-old boy with XLA, after probable maternal transmission of hepatitis B virus. The authors consider that the vertical transmission of hepatitis B virus might play an important role in the development of HCC in a child with XLA who could not eliminate hepatitis B virus effectively.
