A treatment should be functional, esthetic, conservative and periodontally healthy in order to meet criteria of an ideal dental procedure. In a prsthodontic patient with horizontal and/or vertical space deficiency, orthodontic tooth movement should be considered as a pre-prosthetic procedure. With a conventional technique, orthodontic treatment is a time-consuming and uncomfortable procedure. Pre-prosthetic orthodontic treatment, however, is no longer difficult procedure with the help of recently developed techniques, such as passive bracketing. The present article outlines the problems and causes of horizontal and vertical space deficiency in prosthodontic patients, and presents efficient pre-prosthetic orthodontic treatment modalities with typical clinical cases.