This paper presents a case study with a multi-degree-of-freedom (MDOF) system where the Floor Response Spectra (FRS) have been derived from a large ensemble of ground motion accelerograms. The FRS are evaluated by the frequency response function which is calculated numerically. The advantage of this scheme over a repetitive time-history analysis of the entire structure for each accelerogram of the set has been highlighted. The present procedure permits generation of FRS with a specified probability of exceedence.