본 연구의 목적은 치료 용량의 비정형적 항정신병 약물(risperidone, olanzapine)의 성 호르몬(prolactin과 testosterone)에 대한 효과를 알아보기 위해 총 91명의 정신분열병 환자들의 혈청에서 prolactin과 testosterone의 농도를 측정하였다(haloperidol 28명, 4~20mg/day ; risperidone 31명, 2~6mg/day ; olanzapine 32명, 5~20mg/day). 그 결과 남자 환자에서 olanzapine 복용자의 혈청 prolactin 농도가 risperidone이나 haloperidol 복용자의 혈청 농도보다 낮았으나 risperidone 복용자와 haloperidol 복용자의 혈청 prolactin 농도는 상호 유의한 차이가 없었다. 여자 환자에서는 olanzapine 복용자의 혈청 prolactin 농도가 risperidone이나 haloperidol 복용자의 혈청 농도보다 낮았으며 risperidone 복용자의 prolactin 농도는 haloperidol 복용자보다 낮았다. 또한 남자, 여자 환자 모두에서 haloperidol, risperidone, olanzapine을 각각 복용한 사람들의 혈청 testosterone 농도는 유의한 차이가 없었다. 위의 결과로 저자는 치료 용량에서 risperidone은 혈청 prolactin 농도를 haloperidol 만큼이나 증가시키지만 olanzapine의 경우 혈청 prolactin 농도에는 영향을 끼치지 않으며 비정형적 항정신병 약물은 testosteron의 농도에는 영향을 끼치지 않는다는 것을 알 수 있었다.
Objectives : The dopamine-blocking effects and the associated side effects(amenorrhea, lactation, sexual dysfunction) of classical antipsychotics in schizophrenic patients have been studied for a long time. The purpose of this study was to find out these effects of new antipsychotics(risperidone, olanzapine) in schizophrenic patients treated with clinically relevant doses. Method : Plasma levels of both prolactin and testosterone were measured in 91 schizophrenic patients(28 taking haloperidol, 4-20mg/day ; 31 taking risperidone, 2-6mg/day ; 32 taking olanzapine, 5-20mg/day). Results : In male schizophrenic patients, the prolactin levels of risperidone group($76.44{pm}38.85ng/ml$) and haloperidol group($60.26{pm}20.74ng/ml$) had no significant difference, but were significantly higher than that of olanzapine($26.90{pm}5.36ng/ml$). In female, the prolactin level of olanzapine group($36.66{pm}17.55$) was significantly lower than those of risperidone($121.7{pm}48.33$) and haloperidol group($161.66{pm}37.53$). And prolactin level of risperidone group was lower than that of haloperidol group. While the testosterone plasma level of risperidone, haloperidol and olanzapine in both male and female schizophrenic patients had no significant difference. Conclusions : At doses known to be effective in popular clinical setting, prolactin level in patients taking risperidone was higher than that of haloperidol, while olanzapine showed no significant difference in terms of prolactin plasma level from haloperidol. New antipsychotics may not influence the testosterone plasma level.
