In human body, catecholamines, such as epinephrine and norepinephrine, can be increased anxiety, blood pressure and pain etc. The inhibitory effects of TENS, electroacupuncture and massage on the release of epinephrine, norepinephrine from sympathetic nerve endings has already been known. However, the effects of silver spike point stimulation on the catecholamines was not well understood. Therefore, the purpose of this study was to characterize the SSP-induced inhibitory effects of catecholamines. The following results were obtained. (1) The studies on urinary catecholamines released that the levels of epinephrine and norepinephrine of continue type SSP stimulation group were significantly lower than those in the control group in human in vivo. (2) The dose-response curves of epinephrine and norepinephrine in rat aortic smooth muscle strips were increased dose dependent manner respectively. However, the contractile response of norepinephrine in rat aortic smooth muscle strips were slightly differentiated. It is concluded that the SSP stimulation reflects to the inhibitory effects of epinephrine and norepinephrine in men. Especially, we believe that the amplitude-frequency modulation, such as continue type a)1d frequency modulation type, of SSP stimulation plays a role in regulating catecholamines.