A single experimental design (alternating treatment design) was used to compare the effects of the mobilization and heat therapy on the pain and mouth opening in patient with temporo-mandibular disorder (TMD). In the mobilization sessions, the physiotherapist performed two methods of the mobilization on the temporo-mandibular joints. In the heat therapy sessions, the patient received infrared and ultrasono on the temporo-mandibular joint. The mobilization and heat therapy were performed on alternate days during 10 days. Pain was measured by visual analogue scale (VAS) and mouth opening was measured by caliper. The results showed that mobilization and heat therapy were effective in pain reduce and mouth opening increase, and mobilization was superior to heat therapy in mouth opening increase and pain reduce.